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Actoprotectors or synthetic adaptogens are compounds that enhance an organism's resilience to physical stress without increasing heat output. [1] Actoprotectors are distinct from other performance-enhancing substances in that they increase physical and psychological resilience via non-exhaustive action. [ 1 ]
The term "adaptogen" refers to non-toxic plants or their extracts purported to diminish stress and support overall wellbeing when consumed. [4] However, the definition of an adaptogen is vague and without adequate scientific evidence, making it impossible to determine what exactly makes a substance an adaptogen.
Limited clinical studies have found that supplementation with various ashwagandha extracts may decrease anxiety and perceived stress, and improve sleep. [ 3 ] [ 4 ] [ 16 ] As the studies used different extract preparations, durations of use, doses, and types of subjects, how ashwagandha may have effects in people remains undetermined, as of 2023.
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For venous insufficiency, the dosage is 2 tablets of 500mg daily. For acute hemorrhoidal attack, the dosage is 6 tablets daily for 4 days, followed by 4 tablets daily over the next 3 days. [15] For chronic venous disease, the dosage is 2 tablets a day for at least 2 months. [16]