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Oxidative phosphorylation (UK / ɒ k ˈ s ɪ d. ə. t ɪ v /, US / ˈ ɑː k. s ɪ ˌ d eɪ. t ɪ v / [1]) or electron transport-linked phosphorylation or terminal oxidation is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing chemical energy in order to produce adenosine triphosphate (ATP).
The ATP generated in this process is made by substrate-level phosphorylation, which does not require oxygen. Fermentation is less efficient at using the energy from glucose: only 2 ATP are produced per glucose, compared to the 38 ATP per glucose nominally produced by aerobic respiration. Glycolytic ATP, however, is produced more quickly.
Oxidative phosphorylation – The last stage of the aerobic system produces the largest yield of ATP – a total of 34 ATP molecules. It is called oxidative phosphorylation because oxygen is the final acceptor of electrons and hydrogen ions (hence oxidative) and an extra phosphate is added to ADP to form ATP (hence phosphorylation).
Serine in an amino acid chain, before and after phosphorylation. In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. [1] This process and its inverse, dephosphorylation, are common in biology. [2] Protein phosphorylation often activates (or deactivates) many enzymes. [3] [4]
The last process in aerobic respiration is oxidative phosphorylation, also known as the electron transport chain. Here NADH and FADH 2 deliver their electrons to oxygen and protons at the inner membranes of the mitochondrion, facilitating the production of ATP. Oxidative phosphorylation contributes the majority of the ATP produced, compared to ...
Anaerobic respiration is correspondingly less efficient than aerobic respiration. In the absence of oxygen, not all of the carbon-carbon bonds in glucose can be broken to release energy. A great deal of extractable energy is left in the waste products. Anaerobic respiration generally occurs in prokaryotes in environments that do not contain oxygen.
If the concentration of oxygen increases, pyruvate is instead converted to acetyl CoA, used in the citric acid cycle, and undergoes oxidative phosphorylation. Per glucose, 10 NADH and 2 FADH 2 are produced in cellular respiration for a significant amount of proton pumping to produce a proton gradient utilized by ATP Synthase. While the exact ...
Oxidative phosphorylation involves two processes — the electron transport chain and chemiosmosis — and occurs in mitochondria. Molecules such as glucose are metabolized to produce acetyl CoA as a fairly energy-rich intermediate.