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Psychedelic therapy (or psychedelic-assisted therapy) is the proposed use of psychedelic drugs to treat mental disorders. [59] As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials, with some exceptions. [34] [60]
Throughout the 1960s, concerns raised about the proliferation of unauthorized use of psychedelic drugs by the general public (and, most notably, the counterculture) resulted in the imposition of increasingly severe restrictions on medical and psychiatric research conducted with psychedelic substances. [26]
Psychedelic therapy (or psychedelic-assisted therapy) refers to the proposed use of psychedelic drugs, such as psilocybin, MDMA, [note 2] LSD, and ayahuasca, to treat mental disorders. [ 58 ] [ 59 ] As of 2021, psychedelic drugs are controlled substances in most countries and psychedelic therapy is not legally available outside clinical trials ...
Research on psilocybin as a medical treatment was restricted until the 1990s because of the sociocultural fear of dependence on this drug. As of 2022, psilocybin is the most commonly researched psychedelic due to its safety and low potential for abuse and dependence. [2]
The following is a list of psychedelic drugs of various chemical classes, including both naturally occurring and synthetic compounds. Serotonergic psychedelics are usually considered the "classical" psychedelics [dubious – discuss], whereas the other classes are often seen as having only secondary psychedelic properties; nonetheless all of the compounds listed here are considered ...
Interest in the drugs tended to focus on either the potential for psychotherapeutic applications of the drugs (see psychedelic psychotherapy), or on the use of hallucinogens to produce a "controlled psychosis", in order to understand psychotic disorders such as schizophrenia. By 1951, more than 100 articles on LSD had appeared in medical ...
MDMA has limited approved medical uses in a small number of countries, [35] but is illegal in most jurisdictions. [36] In the United States, the Food and Drug Administration (FDA) is evaluating the drug for clinical use as of 2021. [37] Canada has allowed limited distribution of MDMA upon application to and approval by Health Canada.
LSD, like many other drugs of recreational use, has been shown to activate DARPP-32-related pathways. [123] The drug enhances dopamine D 2 receptor protomer recognition and signaling of D 2 –5-HT 2A receptor complexes, [124] which may contribute to its psychotropic effects. [124]