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Lisinopril is indicated for the treatment of hypertension, ... Serious side effects may include low blood pressure, liver problems, hyperkalemia, and angioedema. [7]
Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969. [ 1 ] : 120 The angioedema appears to be dose dependent as it may resolve with decreased dose.
Treatment of acquired angioedema is separated into two main parts. First controlling acute symptoms during angioedema attacks is crucial for preventing and lowering the risk of mortality. [20] Second, managing AAE chronically with prophylactic treatment is important to improve prognosis and quality of life. [20]
Treatment should be mainly symptomatic and supportive, with volume expansion using normal saline to correct hypotension and improve renal function, and gastric lavage followed by activated charcoal and a cathartic to prevent further absorption of the drug. Captopril, enalapril, lisinopril and perindopril are known to be removable by hemodialysis.
Treatment to protect the airway may include intubation or cricothyroidotomy. [1] Histamine-related angioedema can be treated with antihistamines, corticosteroids, and epinephrine. [1] In those with bradykinin-related disease a C1 esterase inhibitor, ecallantide, or icatibant may be used. [1] Fresh frozen plasma may be used instead. [1]
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