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Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.
In a typical product, the drug is triturated with c. 1700 times its mass of sugar before being compressed and coated to produce the final tablet. [ 2 ] In juicing , a triturating juicer is a style of juicer used to break down fresh produce into juice and fiber.
Recognizing drug candidates with potentially suboptimal TI at the earliest possible stage helps to initiate mitigation or potentially re-deploy resources. TI is the quantitative relationship between pharmacological efficacy and toxicological safety of a drug, without considering the nature of pharmacological or toxicological endpoints themselves.
Titration may also refer to: Acid–base titration, based on the neutralization reaction; Complexometric titration, based on the formation of a complex between the analyte and the titrant; Drug titration, medical dose titration, the stepwise titration of doses to determine a desired effect; Redox titration, based on an oxidation-reduction reaction
A titration curve is a curve in graph the x-coordinate of which represents the volume of titrant added since the beginning of the titration, and the y-coordinate of which represents the concentration of the analyte at the corresponding stage of the titration (in an acid–base titration, the y-coordinate usually represents the pH of the solution).
The term dose titration, referring to stepwise adjustment of doses until a desired level of effect is reached, is common in medicine. Engineering The ...
There are multiple indications for switching antipsychotics, including inadequate efficacy and drug intolerance. There are several strategies that have been theorized for antipsychotic switching, based upon the timing of discontinuation and tapering of the original antipsychotic and the timing of initiation and titration of the new antipsychotic.