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The flat line is the optimal blood sugar level (i.e. the homeostatic set point). Blood sugar levels are balanced by the tug-of-war between 2 functionally opposite hormones, glucagon and insulin. Blood sugar levels are regulated by negative feedback in order to keep the body in balance.
The second phase is a slow release of newly formed vesicles that are triggered regardless of the blood sugar level. Glucose enters the beta cells and goes through glycolysis to form ATP that eventually causes depolarization of the beta cell membrane (as explained in Insulin secretion section of this article). The depolarization process causes ...
Negative feedback at work in the regulation of blood sugar. Flat line is the set-point of glucose level and sine wave the fluctuations of glucose. Blood sugar levels are regulated within fairly narrow limits. [39] In mammals, the primary sensors for this are the beta cells of the pancreatic islets.
Negative feedback loops also play an integral role in maintaining the atmospheric balance in various systems on Earth. One such feedback system is the interaction between solar radiation, cloud cover, and planet temperature. Blood glucose levels are maintained at a constant level in the body by a negative feedback mechanism.
Thus, higher hormone concentration alone cannot trigger the negative feedback mechanism. Negative feedback must be triggered by overproduction of an "effect" of the hormone. [32] [33] Blood glucose levels are maintained at a constant level in the body by a negative feedback mechanism. When the blood glucose level is too high, the pancreas ...
This process is illustrated by the insulin receptor sites on target cells, e.g. liver cells, in a person with type 2 diabetes. [6] Due to the elevated levels of blood glucose in an individual, the β-cells (islets of Langerhans) in the pancreas must release more insulin than normal to meet the demand and return the blood to homeostatic levels. [7]