Ad
related to: hypophosphatasia in canada wikipedia english- How to diagnose HPP
Look for signs & symptoms + low ALP
A blood test can support diagnosis
- Common HPP misdiagnoses
HPP can resemble other conditions
Learn how to differentiate HPP
- How to diagnose HPP
Search results
Results From The WOW.Com Content Network
Hypophosphatasia (/ ˌ h aɪ p oʊ ˈ f ɒ s f eɪ t ˌ eɪ ʒ ə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP [6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]
Cheryl Rockman-Greenberg (born September 26, 1950) is a Canadian physician and educator. She was inducted into the Canadian Medical Hall of Fame in 2018. [1] [2] Cheryl has two children, Matthew and Michelle.
Hypophosphatasia is caused by a genetic defect of tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme that plays a role in bone mineralization. Asfotase alfa is a recombinant glycoprotein that contains the catalytic domain (the active site) of TNSALP. It is thus a form of enzyme replacement therapy. [5] [12]
Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. [1] Symptoms may include weakness, trouble breathing, and loss of appetite. [1]
Mutations in the ALPL gene lead to varying low activity of the enzyme tissue-nonspecific alkaline phosphatase (TNSALP or TNAP) resulting in hypophosphatasia (HPP). [21] There are different clinical forms of HPP which can be inherited by an autosomal recessive trait or autosomal dominant trait, [ 18 ] the former causing more severe forms of the ...
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
[8] [9] The Stenciling Principle for mineralization is particularly relevant to the osteomalacia and odontomalacia observed in hypophosphatasia (HPP) and X-linked hypophosphatemia (XLH). The most common cause of osteomalacia is a deficiency of vitamin D, which is normally derived from sunlight exposure and, to a lesser extent, from the diet. [10]
Canada's post-war economic growth, combined with the policies of successive Liberal governments, led to the emergence of a new Canadian identity, marked by the adoption of the maple leaf flag in 1965, [90] the implementation of official bilingualism (English and French) in 1969, [91] and the institution of official multiculturalism in 1971. [92]
Ad
related to: hypophosphatasia in canada wikipedia english