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Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers. TNBC is the most challenging breast cancer type to treat. [5]
The pink ribbon is an international symbol of breast cancer awareness. Pink ribbons, and the color pink in general, identify the wearer or promoter with the breast cancer brand and express moral support for people with breast cancer. Pink ribbons are most commonly seen during National Breast Cancer Awareness Month.
[13] [14] [15] Mono-allelic FANCM mutations are associated with breast cancer risk and especially with risk of developing ER-negative and TNBC disease subtypes. [16] [17] [18] A founder mutation in the Scandinavian population is also associated with a higher than average frequency of triple negative breast cancer in heterozygous carriers. [19]
One of these — triple-negative breast cancer (TNBC) — is an aggressive type of breast cancer that tends to grow and spread rapidly, and has a worse prognosis than other breast cancers.
3. "The current standard for treating patients with clinical stage 2 or 3 triple-negative breast cancer is to administer chemotherapy in addition to immunotherapy prior to surgery. This ...
Mackey's “first ever mammogram,” led to a biopsy that diagnosed her with stage 3 triple negative breast cancer. The mom of two daughters, 3 and 6 at the time, felt ready to act.
Conversely, triple negative cancer (i.e. no positive receptors), lacking targeted treatments, now has a comparatively poor prognosis. [42] [43] Androgen receptor is expressed in 80-90% of ER+ breast cancers and 40% of "triple negative" breast cancers. Activation of androgen receptors appears to suppress breast cancer growth in ER+ cancer while ...
Symbol: miR-146: Alt. Symbols: MIR146 ... mir-146 expression is associated with survival in triple negative breast cancer. [7 ... miR-146 operates in a feedback ...