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Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). [3] [4] Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. [5]
The Chronic Thromboembolic Pulmonary Hypertension sGC-Stimulator Trial (CHEST) was a randomized, placebo-controlled trial aimed to analyse the efficacy and safety of riociguat in CTEPH patients. [20] After a 16-week riociguat treatment the patient's exercise capacity were evaluated by measuring the change in the six-minute walk test (6-MWT). [21]
A Polycyclic aromatic hydrocarbon (PAH) is a class of organic compounds that is composed of multiple aromatic rings.Most are produced by the incomplete combustion of organic matter— by engine exhaust fumes, tobacco, incinerators, in roasted meats and cereals, [1] or when biomass burns at lower temperatures as in forest fires.
The AhR-mediated activities of Cl-PAHs have been determined by using yeast assay systems. Aryl Hydrocarbon Receptor (AhR) is a cytosolic, ligand-activated transcription receptor. Cl-PAHs have the ability to bind to and activate the AhR. The biological pathway involves translocation of the activated AhR to the nucleus.
PAH world hypothesis, hypothesis that proposes that the use of polycyclic aromatic hydrocarbons was a means for the origin of life Polyallylamine hydrochloride , a polyelectrolyte used in polymer sheets
One of the focuses of Actelion is treating individuals with pulmonary arterial hypertension (PAH), a heart condition that leaves patients with a short life expectancy (7–9 years) even with treatment. [5] Actelion scientists were among the first to work in the field of endothelin receptor antagonists. [6]
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