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Phenylalanine hydroxylase (PAH) (EC 1.14.16.1) is an enzyme that catalyzes the hydroxylation of the aromatic side-chain of phenylalanine to generate tyrosine.PAH is one of three members of the biopterin-dependent aromatic amino acid hydroxylases, a class of monooxygenase that uses tetrahydrobiopterin (BH 4, a pteridine cofactor) and a non-heme iron for catalysis.
A Polycyclic aromatic hydrocarbon (PAH) is a class of organic compounds that is composed of multiple aromatic rings.Most are produced by the incomplete combustion of organic matter— by engine exhaust fumes, tobacco, incinerators, in roasted meats and cereals, [1] or when biomass burns at lower temperatures as in forest fires.
Three major signaling pathways involved in the pathogenesis of pulmonary arterial hypertension. The molecular mechanism of pulmonary arterial hypertension (PAH) is not known yet, but it is believed that the endothelial dysfunction results in a decrease in the synthesis of endothelium-derived vasodilators such as nitric oxide and prostacyclin. [41]
The AhR-mediated activities of Cl-PAHs have been determined by using yeast assay systems. Aryl Hydrocarbon Receptor (AhR) is a cytosolic, ligand-activated transcription receptor. Cl-PAHs have the ability to bind to and activate the AhR. The biological pathway involves translocation of the activated AhR to the nucleus.
In Europe, the prevalence ranges from 15-60 cases per year. More than half of PAH is believed to be idiopathic, drug induced or heritable. [6] Disease specific therapy involves targeting the various aberrant pathways involved in the disease. PDE5 inhibitors are used which cause dilation of blood vessels. Riociguat also causes vasodilation.
The PAH world hypothesis is a speculative hypothesis that proposes that polycyclic aromatic hydrocarbons (PAHs), known to be abundant in the universe, [1] [2] [3] including in comets, [4] and assumed to be abundant in the primordial soup of the early Earth, played a major role in the origin of life by mediating the synthesis of RNA molecules, leading into the RNA world.
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