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The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. [3] In solution, however, the dimers dissociate via scission of one Zn-O bond ...
If you’ve ever dealt with acne, you're probably familiar with certain skincare ingredients that are recommended for treating breakouts like salicylic acid, benzoyl peroxide and retinol. Each of ...
Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone was first synthesized in 1979 by Schwarzkopf-Henkel (Germany). It is often used in anti- dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.
Seborrhoeic dermatitis (also spelled seborrheic dermatitis in American English) is a long-term skin disorder. [4] Symptoms include flaky, scaly, greasy, and occasionally itchy and inflamed skin. [2][3] Areas of the skin rich in oil -producing glands are often affected including the scalp, face, and chest. [4]
Imidazole antifungals. Only a few imidazole antifungals are effective against seborrheic dermatitis. Ketoconazole was found to be the most active against Pityrosporum ovale. It is available in both oral and topical formulations. It is also available as cream, gel and tablet. Unlike other drugs, it does not cause skin irritation or phototoxicity.
Pyrithione is the common name of an organosulfur compound with molecular formula C 5 H 5 NOS, chosen as an abbreviation of pyridinethione, and found in the Persian shallot. [4] It exists as a pair of tautomers, the major form being the thione 1-hydroxy-2(1H)-pyridinethione and the minor form being the thiol 2-mercaptopyridine N-oxide; it crystallises in the thione form. [5]