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Polycythemia vera (PCV) (a.k.a. polycythemia rubra vera (PRV)) occurs when excess red blood cells are produced as a result of an abnormality of the bone marrow. [3] Often, excess white blood cells and platelets are also produced. A hallmark of polycythemia vera is an elevated hematocrit, with Hct > 55% seen in 83% of cases. [19]
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [ 2 ] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Polycythemia is made from 3 Greek words. Poly (many), cyto (hollow vessel or cell), & hema (blood) as it's a disease of too many blood cells. Polycythemia vera rubra is one type of this disease & vera is Latin for 'true' & rubra for 'red' since persons with this disease often show an unusually ruddy complexion.
Miliaria rubra is also known as prickly heat and heat rash. [6] Differential diagnosis should be used to rule out polycythemia vera, which is a rare hematological disorder and appears more often in males than females, generally not before the age of 40. Both disorders share a common trait of appearing after taking a hot shower.
Pityriasis rubra pilaris refers to a group of chronic disorders characterized by reddish orange, scaling plaques and keratotic follicular papules. [2]: 442 Symptoms may include reddish-orange patches (Latin: rubra) on the skin, severe flaking (Latin: pityriasis), uncomfortable itching, thickening of the skin on the feet and hands, and thickened bumps around hair follicles (Latin: pilus for hair).
Relation between ESR (Erythrocyte Sedimentation Rate) and Zeta potential (ζ, in mV) in Polycythemia: ζ decrease is due to higher RBC aggregation (Erythrocyte Aggregation, EA). ESR is directly linked to EA. Higher ESR, higher EA. On the other hand lower EA means higher ζ.
Louis Henri Vaquez (27 August 1860 – 15 April 1936) was a French internist born in Paris. He is known for his work in the field of hematology and his research of heart disease. In 1890 he earned his medical doctorate, and in 1895 became médecin des hôpitaux in Paris. In 1898 he was promoted to professeur agrégé, and in 1918 was appointed ...
981TME683S. KEGG. D11027. Ropeginterferon alfa-2b, sold under the brand name Besremi, is a medication used to treat polycythemia vera. [2][3][4][5] It is an interferon. [2][4] It is given by injection. [2][4] The most common side effects include low levels of white blood cells and platelets (blood components that help the blood to clot), muscle ...