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Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from a pheochromocytoma , a tumor of the adrenal medulla : hence the name.
InterPro. Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]
CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity. The association of CALCRL with different RAMP proteins produces different receptors: [6][7] with RAMP1: produces a CGRP receptor. with RAMP2: produces an adrenomedullin (AM) receptor, designated ...
Amylin family. In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family is a family of proteins, which includes the precursors of calcitonin / calcitonin gene-related peptide (CGRP), islet amyloid polypeptide (IAPP) and adrenomedullin . Calcitonin [1] is a 32 amino acid polypeptide hormone that causes a rapid but ...
ADM2. ADM2 is a protein that in humans is encoded by the ADM2 gene. [ 5][ 6] ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues . [supplied by OMIM] [ 6]
Cornish, Jillian, Ian Reginald Reid, and Garth James Smith Cooper. "Treatment of bone disorders with adrenomedullin or adrenomedullin agonists." U.S. Patent 6,440,421, issued 27 August 2002. Reid, Ian Reginald, Jillian Cornish, Garth James Smith Cooper, and David H. Coy. "Compounds and uses thereof in treating bone disorders."
117194 243978 Ensembl ENSG00000183695 ENSMUSG00000074109 UniProt Q96LB1 Q3UG50 RefSeq (mRNA) NM_001303615 NM_054030 NM_001034868 RefSeq (protein) NP_001290544 NP_473371 NP_001030040 Location (UCSC) Chr 11: 19.05 – 19.06 Mb Chr 7: 48.13 – 48.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by ...
GPR182. GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. [5] When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. [6]