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These patients may even have blood on their rectal exam, due to passing small amounts of stool around the ulcer and adjacent fecaloma. [2] Patients may have unstable vital signs if they have been having rectal bleeding, have developed stercoral colitis, and/or have had a perforation of the ulcer.
Solitary rectal ulcer syndrome (SRUS) is a rare benign disease characterized by symptoms, clinical findings, and histological abnormalities. [9] Only 40% of patients have ulcers; 20% of patients have a single ulcer, and the remaining lesions range in size and form from broad-based polypoid to hyperemic mucosa. [10]
Attempts at removal can have severe and even lethal effects, such as the rupture of the colon wall by catheter or an acute angle of the fecaloma (stercoral perforation), followed by sepsis. It may also lead to stercoral perforation, a condition characterized by bowel perforation due to pressure necrosis from a fecal mass or fecaloma. [14] [15]
All of the patients showed resolved symptoms and mucosal injury one year after the procedure. In the long term, 1 patient developed recurrence after 4 years, and the other 7 who were evaluated in the long term did not develop recurrence. [13] Another study combined laparoscopic ventral rectopexy and biofeedback for 48 patients with SRUS.
An anti-TL1A monoclonal antibody called tulisokibart may help people with moderate to severe ulcerative colitis achieve clinical remission, a phase 2 trial has found.
It can also be idiopathic (see colitis), vascular (as in ischemic colitis), or autoimmune (as in inflammatory bowel disease). [citation needed] Diagnosis.
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