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Retinyl palmitate, or vitamin A palmitate, is the ester of retinol and palmitic acid, with formula C 36 H 60 O 2. It is the most abundant form of vitamin A storage in animals. [2] An alternate spelling, retinol palmitate, which violates the -yl organic chemical naming convention for esters, is also frequently seen. [citation needed]
Retinol is reversibly converted to retinal, then irreversibly to retinoic acid, which activates hundreds of genes. [9] Vitamin A deficiency is common in developing countries, especially in Sub-Saharan Africa and Southeast Asia. Deficiency can occur at any age but is most common in pre-school age children and pregnant women, the latter due to a ...
Vitamin A in food exists either as preformed retinol – an active form of vitamin A – found in animal liver, dairy and egg products, and some fortified foods, or as provitamin A carotenoids, which are plant pigments digested into vitamin A after consuming carotenoid-rich plant foods, typically in red, orange, or yellow colors. [27]
Retinyl acetate (retinol acetate, vitamin A acetate) is a natural [dubious – discuss] form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.
Assessing vitamin A status in persons with subtoxicity or toxicity is complicated because serum retinol concentrations are not sensitive indicators in this range of liver vitamin A reserves. [21] The range of serum retinol concentrations under normal conditions is 1–3 μmol/L and, because of homeostatic regulation, that range varies little ...
Retinol was discovered in 1909, isolated in 1931, and first made in 1947. [6] [7] It is on the World Health Organization's List of Essential Medicines. [8] Retinol is available as a generic medication and over the counter. [1] In 2021, vitamin A was the 298th most commonly prescribed medication in the United States, with more than 500,000 ...
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2] All-trans-retinoic acid is required for chordate animal development, which includes all higher animals from fish to ...
Regulation of transport and metabolism of retinol necessary for a successful pregnancy is accomplished via RBP. Retinol-binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, clearly indicating that RBP plays a role in proper retinol exposure to the embryo and successful ...