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The mammillary bodies also mamillary bodies, are a pair of small round brainstem nuclei. [2] They are located on the undersurface of the brain that, as part of the diencephalon , form part of the limbic system .
The bundles of fibers come together in the midline of the brain, forming the body of the fornix. The lower edge of the septum pellucidum (the membrane that separates the lateral ventricles) is attached to the upper face of the fornix body. The body of the fornix travels anteriorly and divides again near the anterior commissure. The left and ...
The interthalamic adhesion (also known as the massa intermedia, intermediate mass or middle commissure) is a flattened band of tissue that connects both parts of the thalamus at their medial surfaces.
The tuber cinereum is a convex mass of grey matter, [3]: 495 a ventral/inferior distention of the hypothalamus forming the floor of the third ventricle. [citation needed] The portion of the tuber cinerum at the base of the infundibulum (pituitary stalk) is the median eminence; [2] the infundibulum extends ventrally/inferiorly from the median eminence to become continuous with the infundibulum.
The mammillary bodies directly or indirectly connect to the amygdala, hippocampus, and thalami as major structures in the limbic system. [6] The mammillothalamic tract carries signals from the mammillary bodies via the anterior thalamus to support spatial memory .
A major output goes via the fornix to the lateral septal area and to the mammillary body of the hypothalamus (which the fornix interconnects with the hippocampus). [21] The hippocampus receives modulatory input from the serotonin , norepinephrine , and dopamine systems, and from the nucleus reuniens of the thalamus to field CA1.
The mammillary bodies form the floor posterior of the tuber cinereum, acting as the link between the fornix and the hypothalamus. Posterior of the mamillary bodies, the ventricle becomes the opening of the cerebral aqueduct, the inferior borders becoming the crus cerebri (sometimes historically called the cerebral peduncle ) of the midbrain .
The anterior nuclei receive afferents from the hippocampus and subiculum directly via the fornix, and indirectly via the mammillary bodies and mammillothalamic tract (MTT). They send efferent fibers to the cingulate gyrus, limbic, and orbitofrontal cortex. [1] The anterior nuclei of the thalamus display functions pertaining to memory.