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  2. Naldemedine - Wikipedia

    en.wikipedia.org/wiki/Naldemedine

    Naldemedine, sold under the brand name Symproic in the US and Rizmoic in the European Union, is a medication that is used for the treatment of opioid-induced constipation in adults who have previously been treated with a laxative in the European Union, or to treat opioid induced constipation in adults with chronic non-cancer pain in the US.

  3. Peripherally acting μ-opioid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Peripherally_acting_μ...

    It has completed phase II in clinical trials in more than 400 patients with OIC. Axelopran has a different chemical structure from other PAMORAs but with a similar mechanism of action. It acts as an antagonist for MOR, KOR and DOR, but with higher affinity for MOR and KOR than for DOR. Like other PAMORAs, the main goal is the treatment of OIC. [34]

  4. Naloxegol - Wikipedia

    en.wikipedia.org/wiki/Naloxegol

    Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]

  5. The best 16 foods to relieve constipation fast ... - AOL

    www.aol.com/news/best-16-foods-relieve...

    Constipation occurs when bowel movements become difficult or infrequent. Usually, constipation is classified as fewer than three bowel movements a week, according to Cleveland Clinic. Another ...

  6. 7. Move more. You may notice that if you take a break from your exercise routine, you get more backed up. “A more sedentary state leads to more constipation,” says Dr. Mathur, who adds that ...

  7. Methylnaltrexone - Wikipedia

    en.wikipedia.org/wiki/Methylnaltrexone

    Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

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