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Pancreatic polypeptide regulates pancreatic secretion activities by both endocrine and exocrine tissues. It also affects hepatic glycogen levels and gastrointestinal secretions. Its secretion in humans is increased after a protein meal, fasting , exercise, and acute hypoglycaemia , and is decreased by somatostatin and intravenous glucose .
Pancreatic polypeptide cells are most active and secrete more pancreatic polypeptide after a meal with high protein, fasting, physical activity, and acute hypoglycemia. These same cells are inhibited by somatostatin, an inhibitory gastrointestinal hormone, and the presence of glucose. [7] Pancreatic Polypeptide From a Mouse Cell
release breast milk Stimulates contraction of cervix and vagina. Involved in orgasm, trust between people, [2] and circadian homeostasis (body temperature, activity level, wakefulness). [3] 50 Pancreatic polypeptide: Peptide: Pancreas: PP cells: pancreatic polypeptide receptor 1: Self-regulation of pancreatic secretions (endocrine and exocrine).
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The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3] Pancreatic progenitor cells have been shown to arise from cells originating from the developing foregut during mammalian development.
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