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Spironolactone can cause breast pain and breast enlargement in women. [128] [129] This is "probably because of estrogenic effects on target tissue." [111] At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]
Breast pain that is not linked to a menstrual cycle is called noncyclic breast pain. Noncyclical breast pain has various causes and is harder to diagnose and frequently the root cause is outside the breast. Some degree of non-cyclical breast tenderness can normally be present due to hormonal changes in puberty (both in girls and boys), in ...
The American College of Obstetricians and Gynecologists (ACOG) also says that hormonal changes the week before a period can cause breast pain and tenderness. Birth control or hormone therapy.
It can cause a range of potential symptoms, including chest pain that can feel like pressure, tightness, pain, squeezing, or aching, as well as fatigue, nausea, and shortness of breath. A heart ...
CPA can sometimes cause breast changes in men including gynecomastia (breast development) and breast tenderness. [10] Rates of gynecomastia of 4 to 30% have been reported. [ 14 ] [ 15 ] [ 16 ] [ 9 ] [ 17 ] Galactorrhea (milk outflow) can also occur in men, due to the strong progestogenic effects of CPA.
[5] [6] [7] Mammoplasia may be due to breast engorgement, which is temporary enlargement of the breasts caused by the production and storage of breast milk in association with lactation and/or galactorrhea (excessive or inappropriate production of milk). [8] Mastodynia (breast tenderness/pain) frequently co-occurs with mammoplasia. [9] [10]