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related to: narcolepsy and insomnia quiz for adults free printable halloween clip art- Cataplexy in Narcolepsy
Gain more insights into the signs
and symptoms of cataplexy.
- Narcolepsy Neurobiology
Sleep-wake state stability, role of
the hypothalamus and histamine.
- Regulating Wakefulness
Discover the role of wake-promoting
neurons in sleep-wake cycle.
- Clinical Assessment
See clinical interview strategies
for identifying ongoing symptoms.
- Tools & Resources
HCPs: Access tools and downloadable
resources for you and your office.
- Diagnosis Resources
View diagnostic criteria for
narcolepsy and find ICD-10 codes.
- Cataplexy in Narcolepsy
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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
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Idiopathic hypersomnia, a primary, neurologic cause of long-sleeping, sharing many similarities with narcolepsy. [83] Insomnia disorder (primary insomnia), chronic difficulty in falling asleep or maintaining sleep when no other cause is found for these symptoms. Insomnia can also be comorbid with or secondary to other disorders.
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It is the only drug authorised by the EMA to treat the whole disease in adults, and by the FDA to treat patients who have cataplexy with the indication to be used for combating excessive daytime sleepiness. [4] [20] This drug helps to normalise sleep architecture and inhibits the intrusion REM sleep elements like paralysis during the day. [4]
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Sleep apnea is the second most frequent cause of secondary hypersomnia, affecting up to 4% of middle-aged adults, mostly men. Upper airway resistance syndrome (UARS) is a clinical variant of sleep apnea that can also cause hypersomnia. [8] Just as other sleep disorders (like narcolepsy) can coexist with sleep apnea, the same is true for UARS.