Search results
Results From The WOW.Com Content Network
Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals. [8] [4] Common side effects include sleepiness, headache, and dry mouth. [8] [9] Serious side effects may include QT prolongation. [9] It is unclear if use during pregnancy or breastfeeding is safe. [8]
Hydrazine is an inorganic compound with the chemical formula N 2 H 4.It is a simple pnictogen hydride, and is a colourless flammable liquid with an ammonia-like odour.Hydrazine is highly hazardous unless handled in solution as, for example, hydrazine hydrate (N 2 H 4 ·xH 2 O).
Hydrazine sulfate is toxic and potentially carcinogenic. [33] [34] Nevertheless, the short-term side effects reported in various clinical trials are relatively mild: [7] minor nausea and vomiting, dizziness and excitement, polyneuritis (inflammation of the nerves) and
Monomethylhydrazine (MMH) is a highly toxic, volatile hydrazine derivative with the chemical formula CH 6 N 2. It is used as a rocket propellant in bipropellant rocket engines because it is hypergolic with various oxidizers such as nitrogen tetroxide (N 2 O 4) and nitric acid (HNO 3). As a propellant, it is described in specification MIL-PRF ...
An applied example is a synthesis of sunitinib begins by mixing 5-fluoroisatin slowly into hydrazine hydrate. [9] After 4 hours at 110 °C, the indole ring structure has been broken into (2-amino-5-fluoro-phenyl)-acetic acid hydrazide with reduction of the ketone at the 3-position.
After F. Raschig developed a method to synthesize hydrazine, Hans Meyer and his doctoral student at the German University in Prague Josef Mally studied hydrazides of pyridinecarboxylic acids. By reacting ethyl isonicotinate with hydrazine hydrate they obtained a compound which, after a recrystallization, had a melting point of 163°C. [6]
Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. [2] This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. [3]
When derived from hydrazine itself, hydrazones condense with a second equivalent of a carbonyl to give azines: [11] R 2 C=N−NH 2 + R 2 C=O → R 2 C=N−N=CR 2 + H 2 O. Hydrazones are intermediates in the Wolff–Kishner reduction. Hydrazones are reactants in hydrazone iodination, the Shapiro reaction, and the Bamford–Stevens reaction to ...