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Adrenocortical carcinoma has often invaded nearby tissues or metastasized to distant organs at the time of diagnosis, and the overall 5-year survival rate is about 50%. [1] Adrenocortical carcinoma is a rare tumor, with incidence of one to two per million population annually.
ATC is an uncommon form of thyroid cancer only accounting for 1-2% of cases, but due to its high mortality, is responsible for 20-50% of deaths from thyroid cancer. [2] The median survival time after diagnosis is three to six months. [2] Some studies report that 10% to 15% survive more than 1 year; 3-year and 5-year survival is very rare.
In the United States there has been an increase in the 5-year relative survival rate between people diagnosed with cancer in 1975-1977 (48.9%) and people diagnosed with cancer in 2007-2013 (69.2%); these figures coincide with a 20% decrease in cancer mortality from 1950 to 2014. [8]
Adrenal cancer is the presence of malignant adrenal tumors, and includes neuroblastoma, adrenocortical carcinoma and some adrenal pheochromocytomas. Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby tissues, but may cause significant health problems by unbalancing hormones.
The prognosis of thyroid cancer is related to the type of cancer and the stage at the time of diagnosis. For the most common form of thyroid cancer, papillary, the overall prognosis is excellent with 97%, 95%, and 90% 10, 15 and 20 year overall survival respectively. [57] The 5 year survival of all thyroid cancers, with treatment, is 98%. [10]
Depending on source, the overall 5-year survival rate for medullary thyroid cancer is 80%, [16] 83% [17] or 86%, [6] and the 10-year survival rate is 75%. [16] By overall cancer staging into stages I to IV, the 5-year survival rate is 100% at stage I, 98% at stage II, 81% at stage III and 28% at stage IV. [18]
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The overall 5-year survival rate for follicular thyroid cancer is 91%, and the 10-year survival rate is 85%. [8] By overall cancer staging into stages I to IV, follicular thyroid cancer has a 5-year survival rate of 100% for stages I and II, 71% for stage III, and 50% for stage IV. [9]