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Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. [1] [2] [3] As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives. [1]
Complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia are those of a typical female (a vulva) Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinized genitalia. [9]
PAIS is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia is that of a typical female, mild androgen insensitivity syndrome (MAIS) is indicated ...
Quigley describes the scale as depicting "severity" or "defective masculinization". Grade 1 is indicated when the external genitalia is fully masculinized, and corresponds to mild androgen insensitivity syndrome. Grades 6 and 7 are indicated when the external genitalia is fully feminized, corresponding to complete androgen insensitivity ...
Those with complete androgen insensitivity syndrome have a 3.6 percent chance of developing a malignant tumor by age 25 and a 33 percent chance by age 50, though malignancy before adulthood is rare. [48] [50] In contrast, partial androgen insensitivity syndrome poses a higher cancer risks if undescended testes are present. [50]
Only at 14, after Kraus did not start menstruating on schedule, was she diagnosed with complete androgen insensitivity syndrome (CAIS). ... Although this is not possible for all people with CAIS ...
This can be explained by the genetics of each syndrome. AIS is an X-linked recessive condition and thus carried over, by females, into future generations (although the most severe form, complete androgen insensitivity syndrome (CAIS), results in sterility, and hence cannot be
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