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  2. Glutathione - Wikipedia

    en.wikipedia.org/wiki/Glutathione

    This reaction is the rate-limiting step in glutathione synthesis. [3] Second, glycine is added to the C-terminal of γ-glutamylcysteine. This condensation is catalyzed by glutathione synthetase. While all animal cells are capable of synthesizing glutathione, glutathione synthesis in the liver has been shown to be essential.

  3. Glutathione synthetase - Wikipedia

    en.wikipedia.org/wiki/Glutathione_synthetase

    Glutathione synthetase (GSS) (EC 6.3.2.3) is the second enzyme in the glutathione (GSH) biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. [2] Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants. [3]

  4. Glutamate–cysteine ligase - Wikipedia

    en.wikipedia.org/wiki/Glutamate–cysteine_ligase

    Glutamate–cysteine ligase (GCL) EC 6.3.2.2), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic pathway that catalyzes the chemical reaction: L-glutamate + L-cysteine + ATP γ-glutamyl cysteine + ADP + P i

  5. Gamma-glutamyltransferase - Wikipedia

    en.wikipedia.org/wiki/Gamma-glutamyltransferase

    Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; [1] EC 2.3.2.2) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate).

  6. Sulfur assimilation - Wikipedia

    en.wikipedia.org/wiki/Sulfur_assimilation

    The biosynthetic pathways of synthesis of γ-glutamylpeptides and alliins are still ambiguous. γ-Glutamylpeptides can be formed from cysteine (via γ-glutamylcysteine or glutathione) and can be metabolized into the corresponding alliins via oxidation and subsequent hydrolyzation by γ-glutamyl transpeptidases.

  7. Lactoylglutathione lyase - Wikipedia

    en.wikipedia.org/wiki/Lactoylglutathione_lyase

    The attack of the glutathione would leave a charged O – and the aldehyde hydrogen bound to C 1. If the carbonyl oxygen of C 2 can secure a hydrogen from an obliging acidic sidechain of the enzyme, forming an alcohol, then the hydrogen of C 1 might simultaneously slide over with its electrons onto C 2 (the hydride transfer).

  8. Buthionine sulfoximine - Wikipedia

    en.wikipedia.org/wiki/Buthionine_sulfoximine

    Buthionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. [1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis.

  9. GCLC - Wikipedia

    en.wikipedia.org/wiki/GCLC

    14629 Ensembl ENSG00000001084 ENSMUSG00000032350 UniProt P48506 P97494 RefSeq (mRNA) NM_001498 NM_001197115 NM_010295 RefSeq (protein) NP_001184044 NP_001489 NP_034425 Location (UCSC) Chr 6: 53.5 – 53.62 Mb Chr 9: 77.66 – 77.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutamate–cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene ...