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The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions. [1] [2] [3] [4]
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication. [5] [11] In 2022, it was the sixteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions.
Dexlansoprazole is used to heal and maintain healing of erosive esophagitis and to treat heartburn associated with gastroesophageal reflux disease (GERD). [2] It lasts longer than lansoprazole, to which it is chemically related, and needs to be taken less often. [8]
Rather than becoming unsafe, they lose potency slowly over time.” If they’re stored in optimal conditions, you can get the most bang for your buck. Best case scenario, the average shelf-life ...
Sucralfate, sold under various brand names, is a medication used to treat stomach ulcers, gastroesophageal reflux disease (GERD), radiation proctitis, and stomach inflammation and to prevent stress ulcers.
Ergocalciferol, also known as vitamin D 2 and nonspecifically calciferol, is a type of vitamin D found in food. It is used as a dietary supplement [3] to prevent and treat vitamin D deficiency [4] due to poor absorption by the intestines or liver disease. [5]
Alfacalcidol (or 1-hydroxycholecalciferol) is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. Alfacalcidol has a weaker impact on calcium metabolism [ 3 ] and parathyroid hormone levels [ 4 ] than calcitriol ; but significant effects on the immune system , including regulatory T cells . [ 5 ]