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Haematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent haematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [ 10 ] [ 11 ] [ 12 ] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an ...
This joint unites long bones and permits free bone movement and greater mobility. [1] The synovial cavity/joint is filled with synovial fluid. The joint capsule is made up of an outer layer of fibrous membrane, which keeps the bones together structurally, and an inner layer, the synovial membrane, which seals in the synovial fluid.
Histology of a synovial membrane. H&E stain. The synovial membrane is variable but often has two layers: [4] The outer layer, or subintima, can be of almost any type of connective tissue – fibrous (dense collagenous type), adipose (fatty; e.g. in intra-articular fat pads) or areolar (loose collagenous type).
The yellow marrow has fatty connective tissue and is found in the marrow cavity. During starvation, the body uses the fat in yellow marrow for energy. [ 7 ] The red marrow of some bones is an important site for blood cell production, approximately 2.6 million red blood cells per second in order to replace existing cells that have been destroyed ...
an inner (synovial membrane, synovial stratum) which is a secreting layer; On the inside of the capsule, articular cartilage covers the end surfaces of the bones that articulate within that joint. The outer layer is highly innervated by the same nerves which perforate through the adjacent muscles associated with the joint.
Despite this low number of MSC's, isolated bone marrow nucleated cells implanted into degenerated human peripheral joints have shown some promise for joint repair. [16] As the number of MSC's that can be isolated from bone marrow is fairly limited, most research in cartilage regeneration has focused on the use of culture-expanded cells.
Finally, the joint capsule matures and forms a cavity, with a central meniscus, and an encasement of synovium. [9] This final structure will form several distinct layers of the articular cartilage found in all synovial joints including the deep zone (closest to the bone), middle zone, and superficial zone (closest to the synovial fluid).
The inner lining of the joint consists of the synovium (also called the synovial membrane), a thin layer located between the joint capsule and the joint cavity. The word "synovium" is derived from the word "synovia" (or synovial fluid ), which is a clear, viscous fluid produced by the synovium, and its main purpose is to reduce friction between ...