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At the same time, there is research suggesting that topical terbinafine — though at a hefty concentration of 10%, not the lower 1% found in Lamisil — can effectively kill toenail fungus with a ...
In some cases, WSO is a misdiagnosis of "keratins granulations" which are not a fungus, but a reaction to nail polish that can cause the nails to have a chalky white appearance. A laboratory test should be performed to confirm. [19] Proximal subungual onychomycosis is fungal penetration of the newly formed nail plate through the proximal nail fold.
Azoles are predominantly fungistatic which inhibit the growth of the fungus instead of killing the fungus. These drugs target the ergosterol biosynthetic pathway by inhibiting the C-14 α-demethylase, a cytochrome P450 enzyme, thus preventing the demethylation of lanosterol to ergosterol which is an essential component of the fungal cell membrane.
This method does not kill the fungus, but the vinegar allegedly changes the pH (acid content) of the new nail formed in that 12-hour period. (The scientific perspective, however, is that vinegar is unlikely to penetrate the dense keratinous tissue thoroughly enough to have any significant effect.
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Before oral antifungal therapies are used to treat nail disease, a confirmation of the fungal infection should be made. [36] Approximately half of suspected cases of fungal infection in nails have a non-fungal cause. [36] The side effects of oral treatment are significant and people without an infection should not take these drugs. [36]