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Molecular Oncology: Receptor-Based Therapy Special issue of Journal of Clinical Oncology (April 10, 2005) dedicated to targeted therapies in cancer treatment; Targeting Targeted Therapy New England Journal of Medicine (2004) Targeting tumors with medicinal cannabis oil – publication list from Spain
In 2015, a phase I clinical trial of PAC-1 opened for enrollment of cancer patients, and in 2016, it was announced that PAC-1 had been granted Orphan Drug Designation for treatment of glioblastoma by the FDA, and in late 2017 a Phase 1b trial began of PAC-1 plus temozolomide for treatment of patients with recurrent glioblastoma or anaplastic ...
Paxalisib (codenamed GDC-0084; pan-class I PI3K and mTOR inhibitor) was tested as a potential treatment for newly diagnosed, unmethylated as well as recurrent glioblastoma in the phase II/III trial GBM AGILE. Kazia reported positive study results for the newly diagnosed, unmethylated population in the concurrent analysis which compares patients ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
Bevacizumab, sold under the brand name Avastin among others, is a monoclonal antibody medication used to treat a number of types of cancers and a specific eye disease. [30] [28] For cancer, it is given by slow injection into a vein (intravenous) and used for colon cancer, lung cancer, ovarian cancer, glioblastoma, hepatocellular carcinoma, and renal-cell carcinoma. [31]
The classification of genetic breast cancer subtypes, including triple-negative and HER2-positive subtypes, [8] have allowed oncologists to use a patient’s breast cancer subtype to personalize cancer therapy schedules.
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