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They generally occur in endocrine organs (e.g. thyroid, parathyroid, and adrenals), but may also occur in endocrine tissues of organs not classically thought of as endocrine. [2] MEN2 is a sub-type of MEN (multiple endocrine neoplasia) and itself has sub-types, as discussed below. Variants in MEN2A have been associated with Hirschsprung disease.
In 1974 Sizemore et al. showed that the MEN 2 category included two groups of patients with MTC and pheochromocytoma: one with parathyroid disease and a normal appearance (MEN 2A) and the other without parathyroid disease but with mucosal neuromas and mesodermal abnormalities (MEN 2B). [citation needed]
Multiple endocrine neoplasia type 2B (MEN 2B) is a genetic disease that causes multiple tumors on the mouth, eyes, and endocrine glands.It is the most severe type of multiple endocrine neoplasia, [2] differentiated by the presence of benign oral and submucosal tumors in addition to endocrine malignancies.
X2 (also marketed as X2: X-Men United, [2] [5] and internationally as X-Men 2) [6] [7] is a 2003 American superhero film directed by Bryan Singer and written by Michael Dougherty, Dan Harris and David Hayter, from a story by Singer, Hayter and Zak Penn. The film is based on the X-Men superhero team appearing in Marvel Comics.
Men of War II is a real-time tactics video game developed by Ukrainian studio Best Way and published by Fulqrum Publishing. As a direct sequel to Men of War , the game features new mechanics and modes and is set on the Eastern and Western Fronts of World War II.
Two and a Half Men is an American television sitcom created by Chuck Lorre and Lee Aronsohn that originally aired on CBS from September 22, 2003, to February 19, 2015, with a total of twelve seasons consisting of 262 episodes.
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Men in Black II (Music from the Motion Picture) is the soundtrack to the 2002 film Men in Black II directed by Barry Sonnenfeld; a sequel to Men in Black (1997) and the second instalment in the eponymous film trilogy starring Will Smith and Tommy Lee Jones, reprising their roles from the predecessor.