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  2. Channel modulator - Wikipedia

    en.wikipedia.org/wiki/Channel_modulator

    Ion channels are typically categorised by gating mechanism and by the ion they conduct. Note that an ion channel may overlap between different categories. Some channels conduct multiple ion currents and some are gated by multiple mechanisms. Examples of targets for modulators include: Voltage-gated ion channels. Calcium channel: see also ...

  3. Chloride channel opener - Wikipedia

    en.wikipedia.org/wiki/Chloride_channel_opener

    Chloride channel openers refer to a specific category of drugs designed to modulate chloride channels in the human body. Chloride channels are anion-selective channels which are involved in a wide variety of physiological functions and processes such as the regulation of neuroexcitation, transepithelial salt transport, and smooth muscle contraction. [1]

  4. Channel blocker - Wikipedia

    en.wikipedia.org/wiki/Channel_blocker

    A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell. Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals.

  5. Biological target - Wikipedia

    en.wikipedia.org/wiki/Biological_target

    The definition is context-dependent, and can refer to the biological target of a pharmacologically active drug compound, the receptor target of a hormone (like insulin), or some other target of an external stimulus. Biological targets are most commonly proteins such as enzymes, ion channels, and receptors.

  6. Chloride channel blocker - Wikipedia

    en.wikipedia.org/wiki/Chloride_channel_blocker

    A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl −) through chloride channels. Niflumic acid is a chloride channel blocker that has been used in experimental scientific research . [ 1 ]

  7. GABA receptor agonist - Wikipedia

    en.wikipedia.org/wiki/GABA_receptor_agonist

    A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels ...

  8. Sodium channel blocker - Wikipedia

    en.wikipedia.org/wiki/Sodium_channel_blocker

    Sodium channel blockers are also used as local anesthetics and anticonvulsants. [5] Sodium channel blockers have been proposed for use in the treatment of cystic fibrosis, [6] but current evidence is mixed. [7] It has been suggested that the analgesic effects of some antidepressants may be mediated in part via sodium channel blockade. [8]

  9. Ion channel - Wikipedia

    en.wikipedia.org/wiki/Ion_channel

    In addition, ion channels are key components in a wide variety of biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, epithelial transport of nutrients and ions, T-cell activation, and pancreatic beta-cell insulin release. In the search for new drugs, ion channels are a frequent ...