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UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
Meta databases are databases of databases that collect data about data to generate new data. They are capable of merging information from different sources and making it available in a new and more convenient form, or with an emphasis on a particular disease or organism.
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In 2002, PIR – along with its international partners, the European Bioinformatics Institute and the Swiss Institute of Bioinformatics – were awarded a grant from NIH to create UniProt, a single worldwide database of protein sequence and function, by unifying the Protein Information Resource-Protein Sequence Database, Swiss-Prot, and TrEMBL ...
The UniProt database is an example of a protein sequence database. As of 2013 it contained over 40 million sequences and is growing at an exponential rate. [ 1 ] Historically, sequences were published in paper form, but as the number of sequences grew, this storage method became unsustainable.
Integrative bioinformatics is one field attempting to tackle this problem by providing unified access. One solution is how biological databases cross-reference to other databases with accession numbers to link their related knowledge together (e.g. so that the accession number stays the same even if a species name changes).
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DisGeNET is an open access resource that makes available a comprehensive knowledge base on disease genes and different tools for their exploitation and analysis. DisGeNET is available through a Web interface , a Cytoscape plugin, [ 2 ] as linked data for the Semantic Web, and supports programmatic access to its data.