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Many factors can result in corneal injury and cause the deterioration or death of cells that make up the cornea of the eye. [5] [12] The epithelial cells that make up the cornea are important in order for normal vision. These cells play a role in creating a physical environment that can correctly bend light rays to help project images to the ...
When applied as a drop or within a strip of paper to the surface of the eye it is used to help detect eye injuries such as foreign bodies and corneal abrasions. [4] [5] When given by mouth or injection into a vein it is used to help evaluate the blood vessels in the back of the eye during fluorescein angiography. [3] [6]
When a cornea is needed for transplant, as from an eye bank, the best procedure is to remove the cornea from the eyeball, preventing the cornea from absorbing the aqueous humor. [ 10 ] There is a global shortage of corneal donations, severely limiting the availability of corneal transplants across most of the world.
Lastly, the cornea is a multifunctional tissue. It provides a large part of the eye's refractive power, meaning it has to maintain remarkable transparency, but must also serve as a barrier to keep pathogens from reaching the rest of the eye, similar to function of the dermis and epidermis in keeping underlying tissues protected.
The corneal endothelium is a single layer of endothelial cells on the inner surface of the cornea.It faces the chamber formed between the cornea and the iris. The corneal endothelium are specialized, flattened, mitochondria-rich cells that line the posterior surface of the cornea and face the anterior chamber of the eye.
Lubricin, which is naturally present in human cornea-eyelid interface, has also been shown to play a key role in reducing friction between the cornea and conjunctiva of the eye. [50] Clinical trials of the use of recombinant lubricin eye drops for treatment of dry eye disease have thus far been relatively successful. [51]