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Although QT interval prolongation is one of the most common reasons for drug withdrawal from the market, the overall incidence of drug-induced QT prolongation is difficult to estimate. [9] One study in France estimated that between 5-7% of reports of ventricular tachycardia , ventricular fibrillation , or sudden cardiac death were in fact due ...
Other drugs which prolong the QT interval include some antipsychotics such as haloperidol and ziprasidone, and the antidepressant citalopram. [31] [19] Lists of medications associated with prolongation of the QT interval such as the CredibleMeds database can be found online. [32]
The mechanism of action of certain antiarrhythmic drugs, like amiodarone or sotalol, involve intentional pharmacological QT prolongation. In addition, high blood alcohol concentrations prolong the QT interval. [30] A possible interaction between selective serotonin reuptake inhibitors and thiazide diuretics is associated with QT prolongation. [31]
Lexapro is one of the most recognizable drug names of our modern era. ... If you have a history of heart problems — such as QT prolongation and heart rhythm disturbance — you should talk to ...
AZCERT focuses on drugs and drug–drug interactions, especially those that cause QT prolongation and Torsades de Pointes (TdP) arrhythmia, and provides its research and its lists of drugs [10] free of charge to the public, healthcare providers, and researchers for personal, professional, and non-commercial purposes. To maintain the ...
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
QT-prolonging medications such as clarithromycin, levofloxacin, or haloperidol, when taken concurrently with cytochrome P450 inhibitors, such as fluoxetine, cimetidine, or particular foods including grapefruit, can result in higher-than-normal levels of medications that prolong the QT interval in the bloodstream and therefore increase a person ...
Concomitant use with drugs that both prolong the QT interval and are metabolized by CYP2D6 (e.g., thioridazine, pimozide); effects on QT interval may be increased Concomitant use with MAOIs or use of MAOIs within 14 days; risk of serious, potentially fatal, drug interactions including serotonin syndrome