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  2. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.

  3. Antibody–drug conjugate - Wikipedia

    en.wikipedia.org/wiki/Antibodydrug_conjugate

    Schematic structure of an antibodydrug conjugate (ADC) Antibodydrug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. [1] Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. As of 2019, some 56 pharmaceutical companies were ...

  4. Category:Monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/Category:Monoclonal_antibodies

    Download as PDF; Printable version; ... Antibody-drug conjugates (57 P) E. ... Pages in category "Monoclonal antibodies"

  5. Monoclonal antibody therapy - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_antibody_therapy

    Liposomes can carry drugs or therapeutic nucleotides and when conjugated with monoclonal antibodies, may be directed against malignant cells. Immunoliposomes have been successfully used in vivo to convey tumour-suppressing genes into tumours, using an antibody fragment against the human transferrin receptor.

  6. Monomethyl auristatin E - Wikipedia

    en.wikipedia.org/wiki/Monomethyl_auristatin_E

    Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.

  7. Monoclonal antibody - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_antibody

    This underpinned the concept of monoclonal antibodies and monoclonal drug conjugates. Ehrlich and Élie Metchnikoff received the 1908 Nobel Prize for Physiology or Medicine for providing the theoretical basis for immunology. By the 1970s, lymphocytes producing a single antibody were known, in the form of multiple myeloma – a cancer affecting ...

  8. Category:Antibody-drug conjugates - Wikipedia

    en.wikipedia.org/wiki/Category:Antibody-drug...

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  9. Nomenclature of monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/Nomenclature_of_monoclonal...

    The nomenclature of monoclonal antibodies is a naming scheme for assigning generic, or nonproprietary, names to monoclonal antibodies. An antibody is a protein that is produced in B cells and used by the immune system of humans and other vertebrate animals to identify a specific foreign object like a bacterium or a virus .