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Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. [1] It is also used to prevent malaria.
[2] [4] [7] It is generally (but not always) less preferred than the tetracycline doxycycline. [4] [7] Minocycline is also used for the treatment of acne and rheumatoid arthritis. [7] [3] It is taken by mouth or applied to the skin. [4] [3] Common side effects include nausea, diarrhea, dizziness, allergic reactions, and kidney problems. [4]
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Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements). Minocycline can be taken with dairy products because it does not chelate calcium as readily, although dairy products do decrease absorption of minocycline slightly. [39]
Systemic doxycycline modified-release capsules are commonly used for the treatment of rosacea. The capsules are taken orally once daily, usually in a low dose, to achieve anti-inflammatory effects. Doxycycline acts by inhibiting inflammation and reducing the production of reactive oxygen species associated with rosacea symptoms.
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Urinalysis is commonly used to help diagnose urinary tract infections, but the significance of the results depends on the broader clinical situation. [13] In the setting of UTI symptoms, positive dipstick results for nitrite and leukocyte esterase are strongly suggestive of a UTI, [ 138 ] [ 139 ] but negative results do not rule it out if there ...