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11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
There is a slight increase in dose proportionality in terms of peak and area-under-the-curve levels of THC with increasing oral doses over a range of 2.5 to 10 mg. [22] A high-fat meal delays time to peak concentrations of oral THC by 4 hours on average and increases area-under-the-curve exposure by 2.9-fold, but peak concentrations are not ...
[2] [3] In the laboratory, researchers have confirmed the effect of cannabis on the perception of time in both humans and animals. [4] Studies have sought to explain how cannabis changes the internal clock. Matthew et al. (1998) looked at the cerebellum, positing a relationship between cerebellar blood flow and the distortion of time perception ...
Polistirex is a polymer that is bonded to the dextromethorphan that requires more time for the stomach to digest it, as it requires that an ion exchange reaction take place prior to its dissolution into the blood. Because of this, dextromethorphan polistirex takes considerably longer to absorb, resulting in more gradual and longer lasting ...
In that time, she warmed to training and made better food choices. As a result, she lost considerable weight and people took notice." Kelly Osbourne ’s fitness journey has been just as public .
Weight loss doctors explain why this exact time might work the best. ... September 30, 2023 at 3:05 AM ... 15 Best Workouts for Weight Loss, ...
In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index, [21] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation. [22]
Participants showed significant impairment 30 minutes after smoking or vaping. And after three hours, when blood THC levels were low, they still felt too stoned to drive safely.
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