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11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
[23] [33] THC is detectable within seconds with inhalation and peak levels of THC occur after 3 to 10 minutes. [3] [33] Smoking or inhaling THC results in greater blood levels of THC and its metabolites and a much faster onset of action than oral administration of THC.
Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), an active component of cannabis. [1]THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked or cooked into cannabis edibles.
In the short-term, such detox diet may lead to weight loss, due to the strict caloric restriction, however after returning to a normal diet there is a weight gain. [19] Although a brief fast of a single day is unlikely to cause harm, prolonged fasting (as recommended by certain detox diets) can have dangerous health consequences or can even be ...
Celebrities’ Weight Loss and Transformations: Before and After Pictures Adele shocked Instagram users with a new photo in May 2020 as she rang in her 32nd birthday in a little black dress.
Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
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