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Anticonvulsants suppress the excessive rapid firing of neurons during seizures. [6] Anticonvulsants also prevent the spread of the seizure within the brain. [7] Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid function. Several antiepileptic drugs have multiple or uncertain mechanisms of action. [8]
Tiagabine, a selective GABA reuptake inhibitor used as an anticonvulsant in the treatment of epilepsy and seizures. Standard reuptake inhibitors are believed to act simply as competitive substrates that work by binding directly to the plasmalemma transporter of the neurotransmitter in question.
Primidone is an anticonvulsant of the barbiturate class; [7] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. [10] The drug’s other active metabolite is phenylethylmalonamide (PEMA). Primidone was approved for medical use in the United States in 1954. [7]
Chemical structure of lamotrigine. Phenyltriazines are a class of molecules containing a phenyl group and a triazine group. These molecules are pharmacologically important. As an example, lamotrigine is a phenyltriazine derivative used as an anticonvulsant drug and has been shown to be useful for alleviating epilepsy [1] and bipolar disorder.
Convulsions are induced in captive animals, then high doses of anticonvulsant drugs are administered. [ 10 ] [ 11 ] [ 12 ] For example, kainic acid can lead to status epilepticus in animals as it is a cyclic analog of l-glutamate and an agonist for kainate receptors in the brain which makes it a potent neurotoxin and excitant.
Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, and generalized anxiety disorder (GAD).
This is a combination of an appetite suppressant called phentermine and an anticonvulsant called topiramate. ... These drugs work by mimicking hormones that reduce appetite. Semaglutide and ...
Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half-life. [84] Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance. [5]