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These symptoms occur due to a lack of normal blood cells. [2] Diagnosis is typically made by blood tests or bone marrow biopsy. [2] The exact cause of leukemia is unknown. [5] A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. [5]
Treatment for chronic lymphocytic leukemias can often be postponed until after the end of the pregnancy. If treatment is necessary, then giving chemotherapy during the second or third trimesters is less likely to result in pregnancy loss or birth defects than treatment during the first trimester. [100]
Virtual karyotyping does not require cell culture and has a dramatically higher resolution than conventional cytogenetics, but cannot detect balanced translocations. Flow cytometry is helpful to identify blasts, abnormal myeloid maturation, and establish the presence of any lymphoproliferative disorder in the marrow.
A new blood test was found to detect colon cancer with more than 80% accuracy — and to rule it out for 90% of healthy people. Doctors speak about how this could improve screening rates and outcomes.
As with most blood tests, false-negatives can happen, meaning results could come back negative when a cancer does exist — although Grail reports that negative cancer test results from Galleri ...
Treatment can occasionally consist of "watchful waiting" (e.g., in CLL) or symptomatic treatment (e.g., blood transfusions in MDS). The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant.