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Members of the defensin family are highly similar in protein sequence. Beta-defensin 2 is an antibiotic peptide which is locally regulated by inflammation. [5] Human beta-defensin 2 is produced by a number of epithelial cells and exhibits potent antimicrobial activity against Gram-negative bacteria and Candida, but not Gram-positive S. aureus ...
In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs (e.g. the epidermis, bronchial tree and genitourinary tract). Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and ...
[25] [26] Human defensins have been thought to act through a similar mechanism, targeting cell membrane lipids as part of their function. In fact human beta-defensin 2 have now been shown to kill the pathogenic fungi Candida albicans through interactions with specific phospholipids. [27]
The human genome contains theta-defensin genes, but they have a premature stop codon, hampering their expression. An artificial human theta-defensin, [40] retrocyclin, was created by 'fixing' the pseudogene, and it was shown to be effective against HIV [41] and other viruses, including herpes simplex virus and influenza A. They act primarily by ...
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13214 Ensembl ENSG00000164825 ENSG00000284881 ENSMUSG00000044748 UniProt P60022 P56386 RefSeq (mRNA) NM_005218 NM_007843 RefSeq (protein) NP_005209 NP_031869 Location (UCSC) Chr 8: 6.87 – 6.88 Mb Chr 8: 22.27 – 22.29 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene. Defensins form a family of microbicidal and ...
New cadets march during Reception Day at the U.S. Military Academy in West Point, N.Y., on June 27, 2016. Credit - Drew Angerer—Getty Images If you’re a member of the Society of Black ...
Instead of moving back 5 yards, Travis Kelce made it down to the 2-yard line. The Chiefs scored the game-winning touchdown on the next play. Refs missed a clear penalty on the Chiefs, which would ...