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Ensitrelvir has been investigated for use as potential post-exposure prophylaxis (PEP) for SARS-CoV-2 infection. [20] [21] The SCORPIO-PEP trial, a global Phase 3 study, assessed the safety and efficacy of ensitrelvir in preventing symptomatic COVID-19 among household contacts of individuals with confirmed SARS-CoV-2 infection.
[9] [10] These drugs had been further developed prior to the COVID-19 pandemic for other diseases including SARS. [11] The utility of targeting the 3CL protease in a real world setting was first demonstrated in 2018 when GC376 (a prodrug of GC373) was used to treat the previously 100% lethal cat coronavirus disease, feline infectious ...
Drinking alcohol will not prevent or cure COVID-19, [16] contrary to some claims. [137] Drinking alcohol may cause subclinical immunosuppression [55] (see "Addictive drugs" section above). Drinking water every 15 minutes was claimed to prevent coronavirus infection. [138]
Trying to self-diagnose a cold, rather than COVID-19, is a "sure fire way to send COVID-19 case rates soaring again," one expert said.
“COVID rebound is a recurrence of COVID symptoms after initial improvement or a new positive test after a negative one,” Dr. Scott Roberts, associate medical director of infection prevention ...
The most recent COVID-19 vaccine should offer protection against the XEC variant, Russo says. “The most recent version of the vaccine seems to be reasonably well-matched,” he says.
Nirmatrelvir/ritonavir has been evaluated in the treatment of COVID‑19 in standard-risk individuals in the EPIC-SR trial. [53] [55] This study did not achieve its primary goal of reducing time to sustained alleviation of COVID‑19 symptoms (treatment: 13 days (95% CI 12–15 days); placebo: 13 days (95% CI 11–14 days)).
The principal for obstetric management of COVID-19 include rapid detection, isolation, and testing, profound preventive measures, regular monitoring of fetus as well as of uterine contractions, peculiar case-to-case delivery planning based on severity of symptoms, and appropriate post-natal measures for preventing infection.