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  2. Primary lateral sclerosis - Wikipedia

    en.wikipedia.org/wiki/Primary_lateral_sclerosis

    Primary lateral sclerosis (PLS) usually presents with gradual-onset, progressive, lower-extremity stiffness and pain due to muscle spasticity. Onset is often asymmetrical. [ 2 ] Although the muscles do not appear to atrophy as in ALS (at least initially), the disabling aspect of PLS is muscle spasticity and cramping, and intense pain when those ...

  3. Papillon–Lefèvre syndrome - Wikipedia

    en.wikipedia.org/wiki/Papillon–Lefèvre_syndrome

    Papillon–Lefèvre syndrome (PLS), also known as palmoplantar keratoderma with periodontitis, [1] [2] is an autosomal recessive [3] genetic disorder caused by a deficiency in cathepsin C. [ 4 ] [ 5 ]

  4. Pityriasis lichenoides chronica - Wikipedia

    en.wikipedia.org/wiki/Pityriasis_lichenoides...

    Although other forms of the disease occur at younger ages, some individuals start having long term symptoms at thirty years of age. This disease also affects adolescents and young adults. This also affects the immune system which therefore results in rashes. The symptoms rarely affect the face or scalp, but occurs at other sites of the body.

  5. List of skin conditions - Wikipedia

    en.wikipedia.org/wiki/List_of_skin_conditions

    The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]

  6. Lichen sclerosus - Wikipedia

    en.wikipedia.org/wiki/Lichen_sclerosus

    Lichen sclerosus (LS) is a chronic, inflammatory skin disease, of unknown cause, which can affect any body part of any person, but has a strong preference for the genitals (penis, vulva), and is also known as balanitis xerotica obliterans when it affects the penis.

  7. Pityriasis lichenoides et varioliformis acuta - Wikipedia

    en.wikipedia.org/wiki/Pityriasis_lichenoides_et...

    Pityriasis lichenoides et varioliformis acuta is a disease of the immune system. It is the more severe version of pityriasis lichenoides chronica. The disease is characterized by rashes and small lesions on the skin. The disease is more common in males and usually occurs in young adulthood, although it has been seen in every age group and every ...

  8. Juvenile primary lateral sclerosis - Wikipedia

    en.wikipedia.org/wiki/Juvenile_Primary_Lateral...

    Juvenile primary lateral sclerosis has an autosomal recessive pattern of inheritance, meaning both copies of the gene in each cell are altered. Juvenile primary lateral sclerosis ( JPLS ) also known as primary lateral sclerosis, juvenile ( PLSJ ), is a very rare genetic disorder , with a small number of reported cases, characterized by ...

  9. Malassezia sympodialis - Wikipedia

    en.wikipedia.org/wiki/Malassezia_sympodialis

    It is considered to be part of the skin's normal human microbiota [2] [6] and begins to colonize the skin of humans shortly after birth. [7] Malassezia sympodialis, often has a symbiotic or commensal relationship with its host, but it can act as a pathogen causing a number of different skin diseases, [8] such as atopic dermatitis. [8] [9]