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Warfarin is indicated for the prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism; [9] prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement; [9] and reduction in the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after ...
An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.
Chiral molecules can differ in their chemical properties, but are identical in their physical properties, which can make distinguishing enantiomers challenging. Absolute configurations for a chiral molecule (in pure form) are most often obtained by X-ray crystallography , although with some important limitations.
Fetal warfarin syndrome is a disorder of the embryo which occurs in a child whose mother took the medication warfarin (brand name: Coumadin) during pregnancy. Resulting abnormalities include low birth weight , slower growth , intellectual disability , deafness , small head size , and malformed bones , cartilage , and joints .
However, the enantiomers are converted into each other in vivo. [18] As a result, dosing with a single-enantiomer form of the drug will still lead to both the enantiomers eventually being present in the patient's serum and thus would not prevent adverse effects—at best, it might reduce them if the rate of in vivo conversion can be slowed. [19]
Coagulation factor X (EC 3.4.21.6), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by F10 gene. [5] It is a serine endopeptidase (protease group S1, PA clan ). Factor X is synthesized in the liver and requires vitamin K for its synthesis.
Ray Romano’s Identical Twin Sons Confront Their Quarter-Life Crisis, Codependency and Growing Up With a Famous Dad in Their New Documentary. Brent Lang. November 8, 2024 at 9:53 AM.
2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq (protein) NP_000497 NP_034298 Location (UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Role of thrombin in the blood coagulation cascade Prothrombin (coagulation factor II) is encoded in the human by ...