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Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [ 1 ] In neurodegenerative diseases , cells of the central nervous system stop working or die via neurodegeneration .
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14] It is the most common neurodegenerative disease. [1]
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Degeneration is deterioration in the medical sense. Generally, it is the change from a higher to a lower form. More specifically, it is the change of tissue to a lower or less functionally active form. True degeneration: when there is actual chemical change of the tissue itself.
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age ( with rare exceptions ) but not all adult animals ...
Tangier disease; TAR syndrome; Tardive dyskinesia; Tarsal tunnel syndrome; Taste disorder; Tatton-Brown–Rahman syndrome; TAU syndrome; Taurodontia absent teeth sparse hair; Taurodontism; Tay syndrome ichthyosis; Taybi–Linder syndrome; Taybi syndrome; Tay–Sachs disease; T-cell lymphoma
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Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5] [6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7] The most common symptoms are joint pain and stiffness. [1]