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Citric acid also dissolves in absolute (anhydrous) ethanol (76 parts of citric acid per 100 parts of ethanol) at 15 °C. It decomposes with loss of carbon dioxide above about 175 °C. Citric acid is a triprotic acid , with pK a values, extrapolated to zero ionic strength, of 3.128, 4.761, and 6.396 at 25 °C. [ 21 ]
Overview of the citric acid cycle. The citric acid cycle—also known as the Krebs cycle, Szent–Györgyi–Krebs cycle, or TCA cycle (tricarboxylic acid cycle) [1] [2] —is a series of biochemical reactions to release the energy stored in nutrients through the oxidation of acetyl-CoA derived from carbohydrates, fats, proteins, and alcohol.
Triethyl citrate is an ester of citric acid. It is a colorless, odorless liquid used as a food additive, emulsifier and solvent (E number E1505) [4] to stabilize foams, especially as whipping aid for egg white. [5] It is also used in pharmaceutical coatings and plastics. [6]
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Citric acid/potassium-sodium citrate is a drug used in the treatment of metabolic acidosis (a disorder in which the blood is too acidic). It is made up of citrate (the weak base of citric acid), a sodium cation and potassium cation. It can also be used for the treatment of kidney stones [1] by treating hypocitraturia. [2]
It functions as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). [5] Citrate synthase is located within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix.