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Doxycycline can be administered via oral or intravenous routes. [1] The combination of doxycycline with dairy, antacids, calcium supplements, iron products, laxatives containing magnesium, or bile acid sequestrants is not inherently dangerous, but any of these foods and supplements may decrease absorption of doxycycline. [64] [65]
Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements). Minocycline can be taken with dairy products because it does not chelate calcium as readily, although dairy products do decrease absorption of minocycline slightly. [39]
Magnesium ions interact with polyphosphate compounds such as ATP, DNA, and RNA. Hundreds of enzymes require magnesium ions to function. Magnesium compounds are used medicinally as common laxatives and antacids (such as milk of magnesia), and to stabilize abnormal nerve excitation or blood vessel spasm in such conditions as eclampsia. [15]
Magnesium salts are available as a medication in a number of formulations. They are used to treat magnesium deficiency, low blood magnesium, eclampsia, and several other conditions. Magnesium is an essential nutrient. Usually in lower dosages, magnesium is commonly included in dietary mineral preparations, including many multivitamin preparations.
Magnesium can also be toxic to plants, although this is typically seen only in drought conditions. [47] [48] Space-filling model of the chlorophyll a molecule, with the magnesium ion (bright-green) visible at the center of the chlorin group. In animals, magnesium deficiency (hypomagnesemia) is seen when the environmental availability of ...
Many drug interactions are due to alterations in drug metabolism. [12] Further, human drug-metabolizing enzymes are typically activated through the engagement of nuclear receptors. [12] One notable system involved in metabolic drug interactions is the enzyme system comprising the cytochrome P450 oxidases.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
Excessive magnesium intake from dietary supplements or medications can cause magnesium toxicity. [1] Magnesium can also interact negatively with several medication types, such as antibiotics and diuretics, so people taking medications regularly should consult with a healthcare provider before starting a magnesium supplement. [1]