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If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...
Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome. [8] It also appears in about 25% of intestinal MALTomas. [citation needed] Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours.
CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. During B cell lymphopoiesis, CD19 surface expression starts during immunoglobulin (Ig) gene rearrangement, which coincides during B lineage commitment from hematopoietic stem cell. [8]
There are approximately twice as many kappa-producing plasma cells as lambda plasma cells. Kappa free-light chains are normally monomeric, while lambda free-light chains tend to be dimeric, joined by disulphide bonds. Polymeric forms of both types of free light chain can also occur. [6]
CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.
943 21941 Ensembl ENSG00000120949 ENSMUSG00000028602 UniProt P28908 Q60846 RefSeq (mRNA) NM_001243 NM_001281430 NM_152942 NM_009401 RefSeq (protein) NP_001234 NP_001268359 NP_033427 Location (UCSC) Chr 1: 12.06 – 12.14 Mb Chr 4: 144.99 – 145.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane ...
CD14 is expressed mainly by macrophages and (at 10-times lesser extent) by neutrophils.It is also expressed by dendritic cells.The soluble form of the receptor (sCD14) is secreted by the liver and monocytes and is sufficient in low concentrations to confer LPS-responsiveness to cells not expressing CD14. mCD14 and sCD14 are also present on enterocytes.
PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells, particularly lymphocytes. It plays a key role in the activation and differentiation of T cells, B cells, and other immune cells by modulating signaling pathways.