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[5] [6] It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. [7] MMP-13 has a predicted molecular weight around 54 kDa. [8] It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain . Although the actual ...
Pyrimidine dicarboxamides are highly selective MMP-13 inhibitors. In the S1’ pocket of MMP-13 is an S1’ side pocket that is unique to the matrix metalloproteiase. Pyrimidine dicarboxamides bind to this side pocket, which increases the selectivity. The role of MMP-13 is cleaving fibrillar collagen at neutral pH and higher mRNA levels of MMP ...
The most commonly used groupings (by researchers in MMP biology) are based partly on historical assessment of the substrate specificity of the MMP and partly on the cellular localization of the MMP. These groups are the collagenases, the gelatinases, the stromelysins, and the membrane-type MMPs (MT-MMPs).
Researchers could link MMP inhibitors to imaging agents to facilitate the detection of tumors before they spread. Though initial trials yielded disappointing results, MMP inhibitors offer significant potential for improving cancer treatment by slowing the process of cancer cell invasion and metastasis. [14]
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors. Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs. [2] Examples include: Batimastat; Cipemastat; Ilomastat; Marimastat; Prinomastat; Rebimastat; Tanomastat
Trans and unsaturated fats: Foods high in these "unhealthy" fats—including fried foods, high-fat condiments (e.g. mayo, cream-based salad dressings, and sauces), and fatty cuts of meat (e.g. red ...
Use our Mediterranean diet foods list to help you get started. Essentials that you always want to have on hand are an assortment of fresh produce, nuts, seeds, high-quality olive oil, and whole ...
The MMP family is formed by twenty related zinc-dependent enzymes. They are noted for having the ability to degrade extracellular matrix proteins, such as collagens , laminin , and proteoglycans . These calcium- and zinc-dependent proteases are activated at neutral pH and twenty-three have been found present in mammalian cells.