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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
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Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit.
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The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is ...