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However, androstanolone is nonetheless described as a very poor anabolic agent. [38] This is attributed to its high affinity as a substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), which is highly expressed in skeletal muscle and inactivates androstanolone into 3α-androstanediol, a metabolite with very weak AR activity. [38]
Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition.
Relative affinities of anabolic steroids and related steroids; Steroid Chemical name Relative binding affinities (%) ; PR Tooltip Progesterone receptor AR Tooltip Androgen receptor ER Tooltip Estrogen receptor
Aside from 5α-reductase, aromatase may inactivate testosterone signaling in skeletal muscle and adipose tissue, so AAS that lack aromatase affinity, in addition to being free of the potential side effect of gynecomastia, might be expected to have a higher myotrophic–androgenic ratio in comparison. [75]
Androstanolone (dihydrotestosterone; DHT) and esters are not available in the United States. Anabolic steroids. Oral, buccal, and/or sublingual. ...
Uniquely among AAS, mesterolone has very high affinity for human serum sex hormone-binding globulin (SHBG), about 440% that of DHT in one study and 82% of that of DHT in another study. [ 17 ] [ 2 ] [ 18 ] As a result, it may displace endogenous testosterone from SHBG and thereby increase free testosterone concentrations, which may in part be ...
Drostanolone, or dromostanolone, is an anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was never marketed. [2] [3] [4] An androgen ester prodrug of drostanolone, drostanolone propionate, was formerly used in the treatment of breast cancer in women under brand names such as Drolban, Masteril, and Masteron.
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